Abstract:

Objective The study was to investigate the alterations and the correlations among reactive oxygen species(ROS), p22phox mRNA expression, and activity of superoxide dismutase(SOD) in aorta of SHRand effects of atorvastain. Methods Wistar-Kyoto(WKY) rats were used as control, SHR were treated with atorvastain 〔50 mg/(kg·d)〕 for 30 days. Blood pressure, levels of serum SOD, nitric oxide(NO), ROS and p22phox mRNA expression in aorta were measured. Results After 30 days' treatment with atorvastain, blood pressure, levels of vascular ROS, and mRNA expression of p22phox in aorta decreased and the levels of serum SOD and NOincreased significantly. Aortic ROS was positively correlated with p22phox mRNA expression and negatively correlated with SOD. Conclusion The increased genesis of aortic ROS in SHRis caused by upregulation of p22phox mRNA expression and reduction of SOD. Atorvastain can reduce ROSby down regulating p22phox expression and increasing SOD.

Key words: spontaneously hypertensive rats, reactive oxygen species, p22phox, superoxide dismutase, atorvastain