Abstract:

Objective To identify prognostic risk factors affecting mortality and morbidity in patients operated on perforated duodenal ulcer by simple suture. Methods Aretrospective analysis of related-prognostic factors was carried out for eighty one patients with perforated duodenal ulcer consecutively operated on by simple suture procedure in Xuanwu hospital between January 1991 and December 2003. Correlative risk factors influencing postoperative hospitalized mortality and morbidity were identified from all analytic factors. Results Postoperative mortality and morbidity were 4.2%(4/95) and 20.0%(19/95) respectively. Multivariate analysis confirmed that only preoperative shock(P=0.002) was a independent predicted mortality significantly, while time from perforation to operation(P=0.002) and concomitant medical illness(P=0.003) were both significant factors that predicted morbidity independently. Conclusion It is important that time from ulcer perforation to operation should be shorten within forty-eight hours for reducing occurrence of shock, the mortality and morbidity will be reduced following the result metioned above. Treatment for older patients with perforated duodenal ulcer should be paid more attention.

Key words: duodenal ulcer, perforation, prognosis