Abstract:

Objective To study the feasibility of the combination of ketamine with lidocaine for anesthesia induction in children. Methods Altogether 40 ASA physical status Ⅰ～Ⅱ children undergoing selective surgery were randomly divided into two groups of 20 each. Group Areceived ketamine and group Breceived the combination of ketamine and lidocaine for induction. Results During the induction, the changes of hemodynamics were observed,the intubation conditions were assessed as acceptable or unacceptable; the post anesthesia side-effects were recorded in all patients. The difference of cardiovascular response between two groups was significant(P<0.05). Although intubation conditions had no significant difference between two groups, laryngoscopy was easier in group Bcompared with group A(P< 0.05) and there was no coughing in group B(P<0.05). No patient in two groups reported post operation psycho-side-effects such as hallucination, but the incidence of post operation nausea and vomiting (PONV) in group Awere higher than those in group B(P<0.05). Conclusion Ketamine-lidocaine anesthetic applied for children induction has the advantages of hemodynamics stability, acceptable intubation conditions and low incidence of PONV. The combination of ketamine with lidocaine for anesthesia induction of children is suitable.

Key words: ketamine, lidocaine, anesthesia induction, children