Association of G894T Polymorphism of Endothelial Nitric Oxide Synthase Gene with Blood Pressure Change

Abstract

Abstract:

Objective To investigate the association of the G894T polymorphism of endothelial nitric oxide synthase (eNOS) gene with blood pressure change in Chinese than nationality population. Method Polymerase chain reaction combined with restriction enzyme digestion was used to detect the polymorphism of eNOS gene in 151 normotensive individuls as control(NT) and 310 hypertensive patients(EH).Results The frequencies of T allele and GT+TT genotype in EH were significantly higher than in NT group;Systolic blood pressure, Diastolic blood pressure, Mean of arterial blood pressure of T allele of eNOS gene G894T polymorphism (20.07±1.81)kPa((150.50± 13.56 )mmHg), (13.33±0.73)kPa((100.01±8.46)mmHg), (15.58±1.05)kPa((116.84±7.84)mmHg) were higher than that of GG genotype ((19.59±1.62)kPa((146.96±12.18)mmHg), (12.99±1.06)kPa((97.44±7.98)mmHg), (15.19±1.0)kPa((113.95±7.49)mmHg)).Conclusion The T allele of G894T polymorphism of eNOS gene is one of risk factors in Chinese hypertensive population.

Key words: essential hypertension, nitric oxide synthase, polymorphism, nitric oxide

CLC Number:

R544.1

Li Dongbao;Hua Qi;Pi Lin. Association of G894T Polymorphism of Endothelial Nitric Oxide Synthase Gene with Blood Pressure Change[J]. Journal of Capital Medical University, 2005, 26(4): 454-456.

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Association of G894T Polymorphism of Endothelial Nitric Oxide Synthase Gene with Blood Pressure Change

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