Abstract:

Objective To analyze the alterations and the causes of coagulation in children with acute lymphoblastic leukemia (ALL) during L-asparaginase(L-asp) treatment and to find out the solutions.Methods 51 ALL patients were analyzedprospectively with 1) changes of APTT,PT,Fib and AT before,during and after treatment of L-asp;comparing the changes different protocols and in different periods of chemotherapy;2) the relationship between coagulation and changes of platelet and(D-dimer) as well as liver function.3) the significance of supplementary therapy in patients with lower AT and/or Fib.Results (1) Fib) and AT were significantly decreased during and at the end of L-asp treatment,but not influenced much by intensity and stages of chemotherapy.2) There were no significant changes of platelets,(D-dimer) and liver function during and at the end of(L-asp).(3) No) thrombosis or hemorrhage occurring after prophylactic supplementary transfusion of AT and/or Fib.Conclusion The negative alterations of Fib and AT were significant in ALL patients during L-asp therapy;These changes were not influenced much by intensity or stages of chemotherapy,neither by liver function;The prophylactic supplementary therapy may reduce the complications of thrombosis and hemorrhage during L-asp treatment.

Key words: acute lymphoblastic leukemia, children, L-asparaginase(L-asp), coagulation