Abstract: Objective To assess the analgesic effects of Transdermal Fentanyl(Durogesic) to moderate or severe cancer patients treated at home.Methods 116 moderate or severe cancer patients with pain received a pain relieving treatment offered by a group of qualified doctors.The trial dosage of Transdermal Fentanyl is 25 μg/h or dosages referred to a conversion formula from morphine to Transdermal Fentanyl.The plaster will be changed with a new one after every 72 h.Dosage could be adjusted according to patients'reaction.Results After follow-up interviews, the effects and adverse reactions of Durogesic were observed.98.27% of patients were observed to relieve pain and the quality of life was significantly improved after use of Transdermal Fentanyl.The minimum dosage of Transdermal Fentanyl was 25 μg/h and the maximum 375 μg/h, average time of treatment was(90.5) d.The main adverse reactions were dizziness, nausea, constipation and skin allergy.Conclusion In summary, Transdermal Fentanyl is a kind of ideal analgesic which has the advantage of convenience and low rate of adverse reactions.It suits moderate or severe cancer patients who treated at home.

Key words: transdermal fentanyl, cancer, pain, pain relief treatment, quality of life