Journal of Capital Medical University ›› 2006, Vol. 27 ›› Issue (1): 28-31.

• 专题报道 • Previous Articles     Next Articles

Effects of Oxymatrine on Anti-inflammatory and ICAM-1 mRNA Expression in Asthmatic Mice

Jiao Xia1, Shen Qiyun2, Wang Limin2, Xu Yiping2, Zhang Liming1   

  1. 1. Department of Respiration, Beijing Chaoyang Hospital Jingxi Campus, Capital University of Medical Sciences;2. Department of Respiration, Shanghai Renji Hospital, Shanghai Second Medical University
  • Received:2005-12-16 Revised:1900-01-01 Online:2006-02-24 Published:2006-02-24

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Abstract: Objective To explore the mechanism of oxymatrine anti-inflammatory and on ICAM-1 mRNA expression.Methods Established a murine model of asthma,investigated the effects of oxymatrine on the total cell number of bronchoalveolar lavage fluid(BALF) and histologic examination,and ICAM-1 mRNA expression by semiquantitative reverse transcription-polymerase chain reaction(RT-PCR) in asthmatic mice.Results 1) Oxymatrine can significantly reduced the total cell number of BALF and markedly improved peribronchial eosinophilic infiltration;2) ICAM-1 mRNA expression was significantly inhibited by oxymatrine,and this may contribute to its antiinflammatory effects.Conclusion Oxymatine can significantly anti-inflammatory and markedly inhibited ICAM-1 mRNA expression in asthmatic mice.

Key words: oxymatrine, asthma mouse model of asthma, anti-inflammatory, cell adhesion molecule

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