Production of IL-12, IL-18 and TNF-α by Alveolar Macrophages in Extrinsic Allergic Alveolitis

Journal of Capital Medical University ›› 2006, Vol. 27 ›› Issue (1): 32-34.

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Production of IL-12, IL-18 and TNF-α by Alveolar Macrophages in Extrinsic Allergic Alveolitis

Tong Zhaohui¹, Chen Baomin¹, Wang Chen¹, Guzman Josune², Costabel Ulrich²

1. Beijing Chaoyang Hospital, Beijing Institute of Respiratory Medicine, Capital University ofMedical Sciences;2. Ruhrlandklinik, University of Essen, 45239 Essen Germany

Received:2005-12-16 Revised:1900-01-01 Online:2006-02-24 Published:2006-02-24

Abstract

Abstract: Objective This study was performed to evaluate the effect of the production of interleukin-12(IL-12),interleukin-18(IL-18) and tumor necrosis factor-α(TNF-α) in the development and pathogenesis of Extrinsic allergic alveolitis(EAA).Methods AM from 11 patients with EAA and 10 control subjects were cultured for 24 h in 10% RPMI medium alone,or with RPMI medium and lipopolysaccharide(LPS,100 μg/L).Cytokines in the culture supernatants were assayed by ELISA.Results The production of IL-18 and TNF-α was increased in patients with EAA in either absence or presence of LPS compared with controls(P<0.05 or P<0.01).Although the spontaneous production of IL-12 was low,with LPS stimulation it was significantly elevated in EAA(P<0.01).Conclusion These observations suggest that IL-12,IL-18 and TNFα may be involved in the pathogenesis of EAA.

Key words: extrinsic allergic alveolitis, alveolar macrophages, cytokine production

CLC Number:

R563.1

Tong Zhaohui;Chen Baomin;Wang Chen;Guzman Josune;Costabel Ulrich. Production of IL-12, IL-18 and TNF-α by Alveolar Macrophages in Extrinsic Allergic Alveolitis[J]. Journal of Capital Medical University, 2006, 27(1): 32-34.

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Production of IL-12, IL-18 and TNF-α by Alveolar Macrophages in Extrinsic Allergic Alveolitis

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