Journal of Capital Medical University ›› 2006, Vol. 27 ›› Issue (1): 35-37.

• 专题报道 • Previous Articles     Next Articles

Researches on the Co-relations between Serum α1-antitrypsin Level and Airway Inflammation, and Pulmonary Function in COPD Patients During the Stationary Phases

Liu Yuxiang, Yang Ting, Ye Yanping, Li Xiaobin, Chen Jin, Ye Huan, He Yaohong, Li Ning, Xi Xiuming   

  1. Department of Respiration Medicine, Beijing Fuxing Hospital, Capital University of Medical Sciences
  • Received:2005-12-16 Revised:1900-01-01 Online:2006-02-24 Published:2006-02-24

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Abstract: Objective To investigate the co-relations between serum α1-antitrypsin level and airway inflammation,and pulmonary function in stable COPD patients.Methods 60 stable COPD patients and 30 healthy controls were recruited.Their serums level of α1-antitrypsin,interleukin-6,interleukin-8 and neutrophil elastase,and the patients pulmonary function as well were detected.Results The findings show that the serum levels of α1-AT,IL-6,IL-8 and NE in COPD patients are much higher than those of the controls;there exist positive correlations between serum levels of α1-AT and NE and negative correlations between serum level of α1-AT and RV/TLC of pulmonary function.Conclusion This indicates that airway inflammation continues during the stationary phases in COPD patients,that the serum α1-AT level are positive with the degree of airway inflammation,and negative with the degree of emphysema.

Key words: chronic obstructive pulmonary diseases, α1-antitrypsin, neutrophil elastase, pulmonary function

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