The Influence of Gene Polymorphism of Aldosterone Synthase Gene CYP11B2 (-344T/C) on RAAS in Han Nationality Essential Hypertensive Patients in Beijing

Abstract

Abstract: CYP11B2(-344T/C) in 345 hypertensive patients (EH) and 156 normotensive controls (NE). Clinic blood pressure, biochemical indexes, the indexes of renin angiotensin-aldosterone system were also detected.Results The frequencies of CC+CT genotype of aldosterone synthase gene CYP11B2(-344T/C) polymorphism among EH was significantly higher than that among NE(P<0.05), the C allele of CYP11B2(-344T/C) polymorphism among EH was significantly higher than that among NE(P<0.01). ALD and ALD/REN of CC+CT genotype of CYP11B2(-344T/C) polymorphism were significantly higher than TT genotype(P<0.05). There were no significant difference in REN and ATⅡ.Conclusion The CYP11B2(-344T/C) polymorphism could significantly influence the RAAS in Han Nationality essential hypertensive patients in Beijing.

Key words: essential hypertension, aldosterone synthase, gene polymorphism, renin-angiotensin-aldosterone system

CLC Number:

R544.1

Hua Qi;Xu Ji;Li Dongbao;Chen Hailing;Guo Jincheng;Liu Rongkun;Yang Zheng . The Influence of Gene Polymorphism of Aldosterone Synthase Gene CYP11B₂ (-344T/C) on RAAS in Han Nationality Essential Hypertensive Patients in Beijing[J]. Journal of Capital Medical University, 2006, 27(3): 361-364.

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The Influence of Gene Polymorphism of Aldosterone Synthase Gene CYP11B₂ (-344T/C) on RAAS in Han Nationality Essential Hypertensive Patients in Beijing

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