Abstract: Objective To establish rat model of epithelial ovarian cancer which clinical character should be similar to human ovarian cancer. Methods Epithelial ovarian cancer cells(NuTu19) were injected intraperitoneally into Fischer344 rat in different cell number. Weight and survival time were observed weekly. Necropsy and pathologic analysis were performed after 4, 8, 16 weeks. Results Mean survival time: 5×10⁶ group was 30 d, 1×10⁶ group was 62 d, 5×10⁵ group was 66 d, 1×10⁵ group was 129 d, 5×10⁴ group was 160 d, 1×10⁴ group was 223 d. Body weight of all rats were raised and ascites were found at three weeks before death. Clinical characters were similar to human ovarian cancer: hemorrhagic ascites, confluent omental mass, peritomeum, diaphragm and intraabdominal organs were implanted numerous tumor nodules. Histological character was papillary serous ovarian adenocarcinoma. Only in terminal stages, ovarian tissues were affected. Conclusion The model is consistent with clinical human ovarian cancer in growth manner, development of disease process, histological type and death complications.

Key words: ovarian cancer, animal model