Abstract: Objective To investigate the possible relationship between the Ⅲ collagen α1(COL3A1) gene and the Chinese sporadic intracranial aneurysms. Methods Obtain the venous blood of the two group cases and extract genomic DNA. After the primer design and synthesis, the polymerase chain reaction(PCR) was performed and the PCR products were examined via the 1% agarose gel electrophoresis, and finally the products were sequenced to investigate the frequency discrepancy of certain single nucleotide polymorphism of COL3A1. Results After statistic analysis, the difference of genotype frequency between the intracranial aneurysms and control group was statistically significant, the P value of which is lower than 0.05. Conclusion There is significant relationship between the functional SNP of COL3A1 gene and sporadic intracranial aneurysms patients and COL3A1 gene would be one of the candidate genes of the Chinese sporadic intracranial aneurysms.

Key words: intracranial aneurysms, single nucleotide polymorphism, COL3A1 gene, genetic polymorphism