Abstract: Objective To explore the effect of simvastatin on high sensitivity C-reactive protein in serum of patients with stable coronary artery disease.Methods 34 patients with stable coronary artery disease at the age of 41～79 years old(26 males and 8 females,mean age at 64.4±11.3 years old) were given 20 mg/d simvastatin at night.The therapeutic course was 12 weeks.Fasting serum total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),high sensitivity C-reactive protein(hs-CRP) and other biochemistry data were examined before and after 4 and 12 weeks' treatment.Results After 12 weeks' treatment,TC,LDL-C,TG significantly decreased by 34.8%,46.1% and 24.7%,but HDL-C increased by 2.0% slightly.76.5% patients could reach Chinese standard level of LDL-C,and the Hs-CRP level decreased significantly(P=0.018).Conclusion The use of 20 mg/d simvastatin is efficacious at lowering LDL-C levels and allowing patients to achieve their goal to low cholesterol level,and may be beneficial to inhibiting inflammatory response in patients with stable coronary artery disease.

Key words: simvastatin, C-reactive protein, coronary artery disease