Effects of Sepsis on the Expression of Glut-1 and Glut-4 mRNA in Rat Diaphragm

Journal of Capital Medical University ›› 2010, Vol. 31 ›› Issue (5): 544-547.

• 呼吸病学专题 • Previous Articles Next Articles

Effects of Sepsis on the Expression of Glut-1 and Glut-4 mRNA in Rat Diaphragm

CHANG Yi¹, NIE Xiu-hong^1*, CAI Yan-ning², CAO Ruo-jin³, FENG Ming³

1. Department of Respiratory Disease, Xuanwu Hospital, Capital Medical University; 2. Department of Nerobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University; 3. Integrative Medical Department, Xuanwu Hospital, Capital Medical University

Received:1900-01-01 Revised:1900-01-01 Online:2010-10-21 Published:2010-10-21
Contact: NIE Xiu-hong

Abstract

Abstract: Objective To investigate the expression of Glut-1 and Glut-4 mRNA in septic rat diaphragmatic muscle. Methods A rat model of septic and control model was established, and the expression of Glut-1 and Glut-4 mRNA in diaphragmatic muscle of SD rats were analyzed by RT-PCR. Results The expression of Glut-1 and Glut-4 mRNA showed an increasing trend with aging and sepsis. Conclusion The imbalance of diaphragmatic carbohydrate metabolism in sepsis plays a vitally important role in sepsis in respiratory dysfunction , especially, the Glut-1 and Glut-4 mRNA expressions in rat diaphragm are altered with age while sepsis effects on Glut-1 and Glut-4 mRNA expressions are age dependent.

Key words: endotoxin, sepsis, diaphragm, glucose transporter

CLC Number:

R 564

CHANG Yi;NIE Xiu-hong;CAI Yan-ning;CAO Ruo-jin;FENG Ming. Effects of Sepsis on the Expression of Glut-1 and Glut-4 mRNA in Rat Diaphragm[J]. Journal of Capital Medical University, 2010, 31(5): 544-547.

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Effects of Sepsis on the Expression of Glut-1 and Glut-4 mRNA in Rat Diaphragm

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