Abstract: Objective To observe the probability of deep venous thrombosis related with central venous catheter(CVC-related DVT), to explore the efficacy and safety of prophylactic anticoagulant therapy for the prevention of CVC-related DVT.
Methods Totally 112 patients who had received CVC insertion were randomly assigned into two groups, the patients in the therapy group were given subcutaneous low-molecular-weight-heparin 0.6 mL once a day and those in the control group were not given any anticoagulant. Color Doppler ultrasound examination was performed for each patient at the end of the first, the second, the forth and the sixth week respectively after CVC insertion to confirm the development of CVC-related DVT. Meanwhile, bleeding complications were observed.
Results The probability of CVC-related DVT in the control group and the therapy group were 12.5%(7/56) and 1.8%(1/56) separately, the difference was statistically significant. No major bleeding complication occurred in therapy group.
Conclusion The probability of CVC-related DVT was significantly higher than that of the control group, the incidence can be reduced by prophylactic anticoagulant therapy with subcutaneous low-molecular-weight-heparin.

Key words: central venous catheters, deep venous thrombosis, pulmonary embolism, prevention, central venous catheter related deep venous thrombosis