Abstract: Psoriasis is an immune-mediated chronic inflammatory skin disease, a variety of cells and cytokines play a dominant role at different stages, inflammatory cells infiltration in the skin and release various cytokines at the onset of and during the course of disease. The chemokine family is characterized by their ability to induce directional migration and activation of leukocytes and non-hematopoietic cells, including endothelial cells to inflammatory sites. Many chemokines may play an important role in the pathogenesis of psoriasis, for example, CCL17 and CCL27 are very important for T-cell tissue homing;CCL2 and CXCL8 are also involved in keratinocyte proliferation and neovascularization. A single nucleotide polymorphisms of the CCL2 and CX3CR1 are associated with psoriasis.

Key words: psoriasis, chemokines, inflammatory cells