Rosiglitazone and Alzheimer’s Disease

doi:10.3969/j.issn.1006-7795.2011.01.019

Journal of Capital Medical University ›› 2011, Vol. 32 ›› Issue (1): 95-99.doi: 10.3969/j.issn.1006-7795.2011.01.019

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Rosiglitazone and Alzheimer’s Disease

ZHANG Xu^1,2, WANG Rong^1,2*#br#

1. Central Laboratory, Beijing Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University; 2. Key Laboratory for Neurodegenerative Diseases, Ministry of Education

Received:1900-01-01 Revised:1900-01-01 Online:2011-02-21 Published:2011-02-21
Contact: WANG Rong

Abstract

Abstract:

In modern aging society, the incidence of Alzheimer’s disease(AD) has been increasing significantly. However, the pathogenesis of AD has not ever been elucidated, and effective treatment for AD is unavailable. Recent study reported that the risk for AD has a high correlation with Type Ⅱ diabetes. There is now an extensive evidence that has demonstrated the efficacy of peroxisome proliferator-activated receptor gamma(PPARγ) agonists rosiglitazone in ameliorating disease-related pathology and improved learning and memory in AD patients and animal models. These evidences and the mechanism of rosiglitazone are reviewed in this paper.

Key words: peroxisome proliferator-activated receptor gamma, rosiglitazone, Alzheimer&rsquo, s disease, amyloid beta, inflammation, apolipoprotein E

CLC Number:

R 741

ZHANG Xu, WANG Rong, . Rosiglitazone and Alzheimer’s Disease[J]. Journal of Capital Medical University, 2011, 32(1): 95-99.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2011.01.019

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2011/V32/I1/95

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Rosiglitazone and Alzheimer’s Disease

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