Role of regulatory T cells in the allergic rhinitis and allergen-specific immunotherapy

doi:10.3969/j.issn.1006-7795.2012.06.005

Journal of Capital Medical University ›› 2012, Vol. 33 ›› Issue (6): 729-734.doi: 10.3969/j.issn.1006-7795.2012.06.005

• 耳鼻咽喉科学学科进展 • Previous Articles Next Articles

Role of regulatory T cells in the allergic rhinitis and allergen-specific immunotherapy

LOU Wei, WANG Chengshuo, ZHANG Luo

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otorhinolaryngology, Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing 100730, China

Received:2012-09-20 Revised:1900-01-01 Online:2012-12-21 Published:2012-12-21

Abstract

Abstract: The immune system is a complex network, and it promptly produces the appropriate immune response to invasion of antigen, bacteria, viruses, etc. The mechanism of the allergic disease is still unclear. However, in recent years, with the understanding of regulatory T cells(Treg cells), people realize that "immune tolerance" plays an important role in the stability of the environment to maintain the body’s immunity. Treg cells play an important role in the induction and maintenance of immune tolerance. This review highlights current knowledge of the role of Treg cells in the mechanism of allergic rhinitis and the antigen-specific immunotherapy.

Key words: regulatory T cells, Foxp3, specific immunotherapy

CLC Number:

R765.21

LOU Wei;WANG Chengshuo;ZHANG Luo. Role of regulatory T cells in the allergic rhinitis and allergen-specific immunotherapy[J]. Journal of Capital Medical University, 2012, 33(6): 729-734.

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Role of regulatory T cells in the allergic rhinitis and allergen-specific immunotherapy

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