Collecting duct carcinoma of the kidney: the analysis of its poor prognosis

doi:10.3969/j.issn.1006-7795.2013.03.009

Abstract

Abstract:

Objective To analyze the prognosis of collecting duct carcinoma (CDC) of the kidney, and the possible reasons that caused its poor prognosis.Methods Through a multicenter retrospective study, the clinical, pathological, operational and adjuvant therapeutic data of 9 CDC cases out of 1 013 renal cell carcinoma (RCC) cases from 4 institutions were recorded and analyzed.Results Nine CDC cases, 0.888% of the total RCC cases, were finally confirmed, in which there were 6 male and 3 female CDC patients with the mean age of 60.8 (range from 37 to 84) years old. Lumbodynia, hematuria, abdominal masses were observed in 6 cases. Three of 9 cases were in AJCC clinical stage I, and the other 6 in stage IV, with the mean tumor volume of 8.2 cm×6.7 cm×5.9 cm. Intrarenal metastasis (5 cases), hematogenous metastasis (6 cases), regional lymph nodes metastases (5 cases), local invasion (2 cases) and liver metastasis (1 case) were histologically observed. Five cases underwent radical nephrectomy (1 case of hand-assistant laparoscopic radical nephrectomy) and 4 underwent palliative nephrectomy (1 case of hand-assistant laparoscopic palliative nephrectomy). Seven cases underwent adjuvant immunotherapy, and 2 cases underwent salvage chemotherapy. The mean follow-up period was 13.7 months (ranged from 7 to 22 months); the mean survival time of 6 patients was 12.7 months.Conclusion The prognosis of CDC was poor. The highly aggressive biological behavior is basically responsible for its prognosis. Due to lack of knowledge of the CDC, the treatment for CDC had no specificity. With the accumulation of the reported cases, the understanding of CDC's prognosis would be more objective.

Key words: renal tumor, renal cell carcinoma, collecting duct carcinoma of the kidney, prognosis

CLC Number:

R 737.11

ZHANG Yinan, WANG Guomin, JIN Xunbo, LIU Yujun, ZHAO Nan, FU Yunfeng. Collecting duct carcinoma of the kidney: the analysis of its poor prognosis[J]. Journal of Capital Medical University, 2013, 34(3): 368-371.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.03.009

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I3/368

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