Clinical study of Zi Gui Nv Zhen capsule to treat the sterility caused by thin endometrium

doi:10.3969/j.issn.1006-7795.2014.02.021

Journal of Capital Medical University ›› 2014, Vol. 35 ›› Issue (2): 248-252.doi: 10.3969/j.issn.1006-7795.2014.02.021

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Clinical study of Zi Gui Nv Zhen capsule to treat the sterility caused by thin endometrium

Wang Haiwen, Ruan Xiangyan

Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China

Received:2013-12-27 Online:2014-04-21 Published:2014-04-16
Contact: 阮祥燕 E-mail:ruanxiangyan@163.com
Supported by:
This study was supported by Beijing Municipality Health Technology High-level Talent(2009-3-52), Project of Discipline Leader, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital(2013-1).

Abstract

Abstract: Objective To evaluate the effectiveness of Zi Gui Nv Zhen capsule on the sterility due to thin endometrium. Methods One hundred and eleven sterility patients with thin endometrium were randomly divided into two groups: observation group of 59 cases and control group of 52 cases. The control group was treated with estradiol valerate. Besides the treatment given to the control group, patients of observation group were given Zi Gui Nv Zhen capsule for treatment. Endometrium thickness, endometrial spiral artery blood flow pulsation index(PI) and endometrial spiral artery blood flow resistance index (RI), luteal phase serum estradiol(E2) and progesterone(P) of after ovulation were observed. Results Observation group proportion of type A endometrium of patients with endometrial thickness increased significantly(P<0.05) compared with the control group. Uterus artery RI in ovulation day of patients who took Zi Gui Nv Zhen capsule was significantly lower than that of the control group(P<0.05), and uterine artery PI was significantly lower than that of the control group(P<0.05). The herbal medicine may reduce uterine artery PI and RI, reduce the uterine artery blood flow resistance and increase the uterine artery blood flow, thus increase blood supply of endometrium, and enhance the receptivity of endometrium. That is beneficial to early embryonic implantation and development. Clinical pregnancy rate of the observation group increased significantly compared to the control group(P<0.05). Conclusion Taking oral Zi Gui Nv Zhen capsule and estradiol valerate treatment on daily basis can enrich the blood supply to the uterus, improve endometrial thickness and type, as well as the receptivity of endometrium; increase the luteal phase of progesterone and estrogen levels, and improve the function of corpus luteum, so as to increase the clinical pregnancy rate.

Key words: Zi Gui Nv Zhen capsule, thin endometrium, sterility

CLC Number:

R271.14

Wang Haiwen, Ruan Xiangyan. Clinical study of Zi Gui Nv Zhen capsule to treat the sterility caused by thin endometrium[J]. Journal of Capital Medical University, 2014, 35(2): 248-252.

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Clinical study of Zi Gui Nv Zhen capsule to treat the sterility caused by thin endometrium

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