Expression of apolioprotein A1 and its correlation with the malignant degree of colorectal cancer

doi:10.3969/j.issn.1006-7795.2014.02.020

Abstract

Abstract: Objective To investigate the expression of apolipoprotein A1 in the serum of different stage and grade patients with colorectal polyp and cancer. We also collected the serum of patients with clinical distant metastasis of colorectal cancer, to find the relationship among apolipoprotein A1 expression and the colorectal tumor aggression and migration. Methods We collected the samples from 59 cases of colorectal tumor patients from Beijing Shijitan Hospital. The patients with colorectal cancer were classified according to the differentiation and invasion of cancer cells by pathologists. The expression of serum apolipoprotein A1 was quantitative identified by immunoturbidimetry and semi-quantitative by Western blotting. SPSS statistical analysis software was used for analyzing the results, P<0.05 was thought to be statistically different. Results The expression of serum apoliopoprotein A1 was lower expressed in the low differentiation of colorectal cancer compared with polyp, high differentiation and middle differentiation groups(P=0.035, P=0.028, P=0.028). Apoliopoprotein A1 was not correlated with the stage and metastases of colorectal cancer. Conclusion The serum apolipoprotein A1 was correlated with the grade of colorectal cancer. Apoliopoprotein A1 could play as a tumor marker for colorectal cancer.

Key words: apolipoprotein A1(APOA1), colorectal cancer, malignancy, Western blotting, immunoturbidimetry

CLC Number:

R730.3

Hu Huihui, Meng Qian, Zhang Man. Expression of apolioprotein A1 and its correlation with the malignant degree of colorectal cancer[J]. Journal of Capital Medical University, 2014, 35(2): 243-247.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2014.02.020

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2014/V35/I2/243

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