The values of serum procalcitonin and endotoxin in diagnosis of the ascitic infection in patients with cirrhosis

doi:10.3969/j.issn.1006-7795.2014.04.014

Abstract

Abstract:

Objective To investigate the clinical value of serum procalcitonin and endotoxin in diagnosis of the ascitic infection in patients with liver cirrhosis. Methods Retrospective study on 61 cirrhotic patients with ascitic infection and 67 cirrhotic patients with sterile ascites in Beijing Youan Hospital from August 2012 to December 2013. The levels of procalcitonin and endotoxin in serum of these patients were analyzed. Results The common pathogens were Enterococcus faecium, Staphylococcus haemolyticus, Escherichia coli, Staphylococcus epidermidis and so on. Mean values of procalcitonin and endotoxin in the ascitic infection group were significantly higher than those in the non-ascitic infection group(P<0.01). ROC curve analysis showed that the areas under the curve of procalcitonin and endotoxin were 0.983 and 0.919, respectively. The sensitivities of procalcitonin and endotoxin were 93.5% and 83.6% respectively, while the specificities were 88.1% and 97.0% respectively in diagnosis of the ascitic infection. Conclusion The serum levels of procalcitonin and endotoxin in cirrhotic patients with ascitic infection both rose and had high sensitivities and specificities. Detections of procalcitonin and endotoxin could be applied in diagnosis of ascitic infection in patients with cirrhosis as fast and accurate auxiliary indicators. The value of procalcitonin was higher especially.

Key words: liver cirrhosis, ascitic infection, procalcitonin, endotoxin

CLC Number:

Dang Yan, Yu Yanhua, Liu Xin, Zhang Lili, Chen Ming, Lou Jinli. The values of serum procalcitonin and endotoxin in diagnosis of the ascitic infection in patients with cirrhosis[J]. Journal of Capital Medical University, 2014, 35(4): 452-455.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2014.04.014

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2014/V35/I4/452

References

[1] 孙立东,张玫,汤哲.337例住院肝硬化患者预后相关因素研究[J].首都医科大学学报,2010,31(3):393-397.

[2] 陈灏珠.实用内科学[M].北京:人民卫生出版社,2004:1854-1855.

[3] 窦晓光.肝硬化并发自发性细菌性腹膜炎的诊断与治疗[J].中华肝脏病杂志,2008,16(6):408-410.

[4] Volk M L, Marrero J A. Advances in critical care hepatology[J]. Minerva Anestesiol, 2006,72:269-281.

[5] European Association for the Study of the Liver. EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis[J]. J Hepatol, 2010,53(3):397-417.

[6] Dandona P, Nix D, Wilson M F, et al. Procalcitonin increase after endotoxin injection in normal subjects[J]. J Clin Endocrinol Metab, 1994,79(6):1605-1608.

[7] Gendrel D, Bohuon C. Procalcitonin as a marker of bacterial infection[J]. Pediatr Infect Dis J, 2000,19(8):679-687.

[8] Guarner C, Soriano G. Bacterial translocation and its consequences in patients with cirrhosis[J]. Eur J Gastroenterol Hepatol, 2005,17(1):27-31.

[9] Han D W. Intestinal endotoxemia as a pathogenetic mechanism in liver failure[J]. World J Gastroenterol, 2002,8(6):961-965.

[10] Kotecha H L, Arora A, Chawlani R, et al. Low eosinophil count predicts in-hospital mortality in cirrhosis with systemic inflammatory response syndrome[J]. Eur J Gastroenterol Hepatol, 2013,25(6):676-682.

[11] 张崴,张世兰,王海滨.肝硬化患者血浆降钙素原与肠黏膜损伤的关系[J].解放军医学杂志,2003,7:622-623.

[12] 王玉文,王筱君.中年男性肝硬化并自发性细菌性腹膜炎的观察及护理[J].临床误诊误治,2012,25(6):102-103.

[13] 张志沛.重型病毒性肝炎并发自发性细菌性腹膜炎56例临床分析[J].中国煤炭工业医学杂志,2012,15(2):188-189.

[14] 魏兆勇,张分明,李松柏,等.慢性肝病合并自发性细菌性腹膜炎20例误诊分析[J].临床误诊误治,2011,24(1):65-66.

[15] Cekin Y, Cekin A H, Duman A, et al. The role of serum procalcitonin levels in predicting ascitic fluid infection in hospitalized cirrhotic and non-cirrhotic patients[J]. Int J Med Sci, 2013,10(10):1367-1374.

[16] Tsung P C, Ryu S H, Cha I H, et al. Predictive factors that influence the survival rates in liver cirrhosis patients with spontaneous bacterial peritonitis[J]. Clin Mol Hepatol, 2013,19(2):131-139.

[17] 代芳芳,赵秀英,等.慢性肝病患者胸腹水标本病原菌检测及耐药性分析[J].北京医学,2013,35:164-167.