Abstract: Objective To investigate the effect of possible influential factors on renal function among patients 1 year after coronary interventions. Methods Totally 287 patients with acute coronary syndrome (ACS) seen from Jan. 2013 to Sep.2013 were enrolled in this retrospective study. All of them were treated with percutaneous coronary intervention (PCI) and followed up for at least 1 year. Then the clinical data were collected and analyzed retrospectively. The patients were divided into two groups according to the estimated glomerular filtration rate (eGFR) decreased or maintained after 1 year follow-up and a Logistic regression analysis was used to analyze the effect of influential factors. Results Compared with eGFR maintained group (n=132), hypertension (HTN) (67.4% vs 55.5%) and non-ST segment elevation ACS (NSTEACS) (58.3% vs 42.6%) were much common in eGFR decreased group (n=155) (P=0.02). There was a statistical significant difference in hemoglobin (HGB) (140.4±17.6g/L vs 140.2±14.3g/L;F=5.384, P=0.02) but no significant difference in age, gender, diabetes mellitus (DM), ischemic stroke (IS) history, cholesterol, glucose, myocardial enzymes, left ventricular ejection fraction (LVEF), dosage of contrast media, number of vessels with stenosis and number of stents implanted in one patient (P > 0.05) between the two groups. The Logistic analysis indicated that HTN and NSTEACS were independent risk factors to influence the eGFR (P=0.01, OR=1.949, 95% CI:1.174-3.237 and P=0.004, OR=2.08, 95% CI:1.265-3.418).Conclusion For ACS patients who received PCI, those who had hypertension and NSTE-ACS were more likely to have decreased eGFR after 1 year follow-up.

Key words: acute coronary syndrome, estimated glomerular filtration rate, percutaneous coronary intervention