Diagnosis of dry eye disease using keratograph 5M

doi:10.3969/j.issn.1006-7795.2017.01.003

Abstract

Abstract: Objective To compare the noninvasive Keratograph tear breakup time (NIKBUT) and tear meniscus height (TMH) of patients with dry eye disease (DED) and healthy control subjects using Keratograph 5M (K5M) and to investigate the role of NIKBUT and TMH in the diagnosis of DED. Methods In this prospective study, 110 eyes with DED (DED group) and 108 healthy control eyes (Control group) were enrolled. All subjects completed the Ocular Surface Disease Index (OSDI) questionnaire. NIKBUT, which included the first NIKBUT (NIKBUTf) and average NIKBUT (NIKBUTav), and TMH were measured by K5M. The fluorescein tear breakup time (BUT), corneal staining and SchirmerⅠ test were also applied. All parameters were compared between the DED and Control groups. The receiver operating characteristic curves (ROC) were plotted to distinguish DED from the normal eyes. Results There were significant difference between DED and Control group for the values of OSDI, BUT, corneal staining score and Schirmer Ⅰ test (all P<0.001). In the DED group, the NIKBUTf, NIKBUTav and TMH were (5.9±3.96) s, (8.07±4.34) s and (0.22±0.06) mm, respectively; while in the Control group, the values were (8.78±4.33) s, (12.67±4.43) s and (0.28±0.09) mm, respectively (between the two groups, all P<0.001). For ROC analysis, the area under the curve (AUC), sensitivity and specificity were 0.740, 80% and 67.59% for NIKBUTf; 0.798, 64.55% and 83.33% for NIKBUTav; 0.660, 33.63% and 94.44% for TMH, respectively. For the combo of the three parameters, the AUC, sensitivity and specificity were 0.829, 67.3% and 86.1%, respectively. Conclusion Keratograph 5M offers an effective method for measuring NIKBUT and TMH properties of both patients with DED and healthy subjects. The three parameters exhibited significant differences between the two groups. Although the diagnostic efficiency was poor with NIKBUT or TMH alone, but the combined parameter showed a high sensitivity for the diagnosis of DED, with practical clinical application.

Key words: dry eye disease, noninvasive Keratograph tear breakup time, tear meniscus height, receiver operating characteristic curves, sensitivity, specificity

CLC Number:

R777

Tian Lei, Song Wenxiu, Wang Zhiqun, Zhang Yang, Sun Xuguang. Diagnosis of dry eye disease using keratograph 5M[J]. Journal of Capital Medical University, 2017, 38(1): 11-16.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.01.003

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I1/11

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