Research progresses in neuroprotective effects of ischemic/hypoxia preconditioning

doi:10.3969/j.issn.1006-7795.2020.04.029

Abstract

Abstract: The brain has poor tolerance to ischemia and hypoxia, which could result in dysfunction and pathological changes of central nervous system. Both endogenous factors such as ischemic stroke and cancer and exogenous factors such as plateau exposure, aviation, and diving can lead to ischemia and hypoxia of the body or organs. Therefore, it is of great significance to develop strategies to improve cerebral hypoxic tolerance to prevent from ischemic and hypoxic diseases. Many studies have shown that exposure to moderate ischemia and hypoxia in a short period of time can significantly strengthen the body's tolerance to subsequent more severe hypoxia. This phenomenon is known as ischemia/hypoxia preconditioning. As a neuroprotective strategy, ischemia/hypoxia preconditioning has become one of the hotspots in biomedical research, and it has been applied in a variety of preclinical models such as ischemic stroke and neurodegenerative diseases. The protective mechanism of ischemia/hypoxia preconditioning is complex, which involves hypoxia signaling pathway activation, antioxidant stress, anti-inflammatory, anti-apoptosis, and so on. In this work, we reviewed the protective mechanisms and the research progresses of ischemia/hypoxia preconditioning to highlight its application potential in the treatment of neurological diseases.

Key words: hypoxia, ischemic, preconditioning, neuroprotection

CLC Number:

Q189

Wu Jian, Gu Yakun, Liu Jia. Research progresses in neuroprotective effects of ischemic/hypoxia preconditioning[J]. Journal of Capital Medical University, 2020, 41(4): 664-670.

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