Study of Animal Model of the PromoPted One Phase Multiple Organ Dysfunction Syndrome in Pigs

Journal of Capital Medical University ›› 2005, Vol. 26 ›› Issue (4): 479-481.

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Study of Animal Model of the PromoPted One Phase Multiple Organ Dysfunction Syndrome in Pigs

Ren Tianhua¹, Jiang Yue², Ren Aimin³, Zhang Shuwen³, Wang Baoen³

1. Department of Gastroeterology, Beijing Tiantan Hospital, Capital University of Medical Sciences;2. Departmentof Cardiovascular, Beijing Tiantan Hospital, Capital University of Medical Sciences;3. Department of Infection andCritical Care, Beijing Friendship Hospital, Capital University of Medical Sciences

Received:2005-03-28 Revised:1900-01-01 Online:2005-08-24 Published:2005-08-24

Abstract

Abstract:

Objective The purpose of the study was to provide a simple and useful MODS animal model.Methods 16 one-year-old male swines whose weight was 20～25 kg were selected. Colon bacillus (17×10⁸/kg)was injected into right jugular. Serum endotoxins, blood routine, blood gas analysis, mean arterial pressure(MAP), heart rate (HR), temperature and breath rate were examined 1, 3, 5, and 7 h after injection respectively.Results 3 h after models were made with standard colon bacillus, all animals had endotoxemia; 5 h later, and 100% animals had MODS.Conclusion An useful animal model of MODS is provided by the present study.

Key words: MODS, animal model, colon bacillus

CLC Number:

Q95.33

Ren Tianhua;Jiang Yue;Ren Aimin;Zhang Shuwen;Wang Baoen. Study of Animal Model of the PromoPted One Phase Multiple Organ Dysfunction Syndrome in Pigs[J]. Journal of Capital Medical University, 2005, 26(4): 479-481.

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Study of Animal Model of the PromoPted One Phase Multiple Organ Dysfunction Syndrome in Pigs

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