Effect of Rhizoma Curcumate Zedoariae, Herbra Trifolii Repentis and IL-6-induced on Apoptosis of Human Breast Cancer Cell Line MCF-7

Journal of Capital Medical University ›› 2006, Vol. 27 ›› Issue (4): 492-493.

• 基础研究 • Previous Articles Next Articles

Effect of Rhizoma Curcumate Zedoariae, Herbra Trifolii Repentis and IL-6-induced on Apoptosis of Human Breast Cancer Cell Line MCF-7

Zhang Jinfeng, Wang Zhe, Liu Xin, Tang Zuoqing, Xie Wenjie, Fu Guifang

Department of Cell Biology and Genetics, Capital University of Medical Sciences

Received:2005-06-30 Revised:1900-01-01 Online:2006-08-24 Published:2006-08-24

Abstract

Abstract: Objective To explore the mechanism of inhibitory effects on breast cancer cell(MCF-7) of two Chinese traditional herbs(rhizoma curcumate zedoariae and herbra trifolii repentis) and IL-6.Methods Human breast cancer cell line MCF-7 was adopted as target cell.Tumor cell apoptosis was investigated by means of flow cytometry.Results The extracts of both herbs induced apoptosis in MCF-7 cells.The combination of two herbs had stronger apoptosis-inducing effect than either alone.The presence of these two herbs enhanced IL-6-induced apoptosis.Conclusion Two herbs,Rhizoma curcumate zedoariae and herbra trifolii repentis induce apoptosis in breast cancer cell line MCF7.This may be one of the mechanisms for anticancer properties of these herbs.

Key words: rhizoma curcumate zedoariae, herbra trifolii repentis, IL-6, MCF-7, apoptosis

CLC Number:

Q279

Zhang Jinfeng;Wang Zhe;Liu Xin;Tang Zuoqing;Xie Wenjie;Fu Guifang. Effect of Rhizoma Curcumate Zedoariae, Herbra Trifolii Repentis and IL-6-induced on Apoptosis of Human Breast Cancer Cell Line MCF-7[J]. Journal of Capital Medical University, 2006, 27(4): 492-493.

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Effect of Rhizoma Curcumate Zedoariae, Herbra Trifolii Repentis and IL-6-induced on Apoptosis of Human Breast Cancer Cell Line MCF-7

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