Journal of Capital Medical University ›› 2000, Vol. 21 ›› Issue (4): 285-288.

• 论著 • Previous Articles     Next Articles

Effect of Anti-CD3 Antibody and Donor Strain Bone Marrow on Mouse Skin Graft Survival

Wang Jianwen1, Wang Zonghui2, Gao Juzhong1, Guan Delin1, Xu Jianjun1, Xia Chengqing3   

  1. Department of Urology, Beijing Red Cross Chaoyang Hospital, Affiliate of Capital University of Medical Sciences
  • Received:1999-12-23 Revised:1900-01-01 Online:2000-10-15 Published:2000-10-15

Abstract: The research is to study the influence on mouse skin graft survival with anti-CD3 antibody and donor bone marrow infusion. Under the effect of the immunosuppression of anti-CD3 antibody, bone marrow cell suspensions were extracted from donor strain C57BL/6 and injected into recipient BALB/C after skin allograft. The MST is 15.6 d for the bone marrow group, 10.1 d for the anti-CD3 group and 7.7 d in the contrast group respectively. The donor specific bone marrow infusion could improve the skin graft survival under the immunosuppression.

Key words: allograft, bone marrow, antibody

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