Alumina Cream-induced Focal Motor Epilepsy in Cats

Abstract

Abstract: Various dosages of alumina cream were spectively injected into the unilateral motor areas in cats in order to study its effect on the development of chronic focal epilepsy. The changes of cats′ behaviors, histological analysis and electroencephalographic(EEG) were observed from two to four months. Histological analysis showed that alumina cream produced an epileptic foci. Spikes were recorded easily during EEG monitoring when injection dosage was increased to 100～150 μL. But none of the cats were observed to occur spontaneous seizures. These results indicated that alumina cream could induced the abnormal changes of EEG in cats, however, because spontaneous seizures were less predicatable and were not observed, the reliability of this preparation in cats as a model of chronic focal epilepsy was debatable.

Key words: alumina, epilepsy, animal model

CLC Number:

R742.1

Zhang Weili;Luan Guoming;Yan Li;Meng He. Alumina Cream-induced Focal Motor Epilepsy in Cats[J]. Journal of Capital Medical University, 2000, 21(2): 137-139.

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Alumina Cream-induced Focal Motor Epilepsy in Cats

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