Relationship between insulin resistance and coagulation indices and platelet parameters in patients with type 2 diabetes mellitus

doi:10.3969/j.issn.1006-7795.2013.01.028

Abstract

Abstract:

Objective To investigate the relationship between insulin resistance(IR)and coagulation indices and platelet parameters in patients with or without type 2 diabetes mellitus (DM). Methods Totally 392 patients with new onset DM and 95 patients with non-diabetes mellitus (NDM) were enrolled. The patients were assigned into four groups (A, B, C and D group) based on the quartile of IR to compare coagulation indices and platelet parameters among the subgroups. Results Significant difference in prothrombin time(PT), activated partial prothrombin time(APTT), platelet distribution width(PDW), mean platelet volume(MPV), platelet-large cell ratio(P-LCR) and low-density lipoprotein cholesterol(LDL-C ) with the level of IR were found among the four subgroups in DM and NDM patients. Also, PT among the four subgroups have significant difference between DM and NDM patients. Interactions were found in coagulation indices (PT and APTT), platelet parameters (PDW, MPV and P-LCR) between the level of IR and whether the patients had DM or not. Conclusion IR could be an independent factor to act on the process of the coagulation of blood. The patients with IR predisposed to present hyper-coagulation state and underlying thrombotic disease.

Key words: type 2 diabetes mellitus, insulin resistance, homeostasis model assessment

CLC Number:

R587.1

YANG Ning, WANG Li, XÜ Yuan, ZHANG Donglei. Relationship between insulin resistance and coagulation indices and platelet parameters in patients with type 2 diabetes mellitus[J]. Journal of Capital Medical University, 2013, 34(1): 144-149.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.01.028

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I1/144

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