Interleukin 1 receptor accessory protein contributes to children and adult low grade gliomas

doi:10.3969/j.issn.1006-7795.2013.02.018

Abstract

Abstract:

Objective To analyze the expression of interleukin 1 receptor accessory protein(IL-1RAP) in children and adult low grade gliomas(LGG) and correlation between the level of this markers and low grade gliomas recurrence. Methods The samples of LGG were collected and divided into two groups(adult group and children group).Gene expression profiles in adult group and children group were compared by microarray. The expression of changed gene was indentified by immunohistochemistry(IHC), Western blot and quantitative real-time PCR(qRT-PCR) in 20 cases of LGG(10 children, 10 adult). Results We identified that IL-1RAP was consistently up-regulated in children group LGG with the adult group LGG by cDNA array, and the level of IL-1RAP in children group was significantly higher than that of adult group detected by RT-PCR, Western blot and IHC(Chi-Square=12.439, P<0.05). Conclusion IL-1RAP may be the potential biomarkers to evaluate the inclination of invasion and recurrence in children and adult low grade gliomas. And the dysregulation of IL-1RAP may be critical for malignant astrocytoma formation, and thus a possible novel universal target for therapeutic intervention.

Key words: interleukin 1 receptor accessory protein(IL-1RAP), low grade gliomas, adult, children

CLC Number:

R730.264

XING Shushan, HU Wanning, ZHAO Xiqing, LIU Wenqing, GONG Jian. Interleukin 1 receptor accessory protein contributes to children and adult low grade gliomas[J]. Journal of Capital Medical University, 2013, 34(2): 258-263.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.02.018

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I2/258

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