Microstructural changes of white matter in obstructive sleep apnea syndrome on diffusional kurtosis imaging study

doi:10.3969/j.issn.1006-7795.2018.02.005

Abstract

Abstract: Objective To analyze the microstructural changes of white matter (WM) in obstructive sleep apnea syndrome (OSAS), and to explore neurophysiological mechanisms of cognitive impairment in patients with OSAS. Methods We used tract-based spatial statistics (TBSS) analysis to compare diffusion and kurtosis parameters in 19 OSAS children and 23 age and gender matched healthy children. Results Compared to healthy controls, the diffusion parameter fractional anisotropy (FA) decreased in WM regions (anterior limb of internal capsule, anterior thalamic radiation, fornix, inferior longitudinal fasciculus and corpus callosum) with coherent fiber arrangement, while the kurtosis parameter kurtosis fractional anisotropy (KFA) decreased in WM regions (superior longitudinal fasciculus and posterior corona radiata) with complex fiber arrangement. The two parameters were sensitive to reveal abnormality of WM in OSAS children. There are multiple abnormal brain lobes in OSAS patients. The KFA values in the right forelimb of internal capsule and the left parietal lobe were positively correlated with lowest oxygen saturation (LSaO₂). The values FA, KFA of DKI parameters in the corpus callosum, right posterior coronaries, left post central and left anterior parietal lobes were negatively correlated with SaO₂ <90% and hypoventilation index. Conclusion The abnormal KFA value existed in multiple brain lobes in OSAS patients, which showed significant positive correlations with hypoxia, which may be mechanism of cognitive impairment for OSAS children.

Key words: obstructive sleep apnea syndrome, tract-based spatial statistics, diffusional kurtosis imaging, children

CLC Number:

R445

Li Wenfeng, Wen Hongwei, Liu Yue, Peng Yun, Cheng Hua, Li Hongbin, Tai Jun. Microstructural changes of white matter in obstructive sleep apnea syndrome on diffusional kurtosis imaging study[J]. Journal of Capital Medical University, 2018, 39(2): 178-184.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.02.005

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I2/178

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