Efficacy comparison of methylprednisolone and dexamethasone treatment of sudden deafness: a system review and Meta-analysis

doi:10.3969/j.issn.1006-7795.2018.02.020

Abstract

Abstract: Objective To analyze methylprednisolone and dexamethasone treatment the curative effect of sudden deafness by Meta analysis. Methods The retrieval of database was performed including CNKI, Wanfang, VIP, CBM, PubMed, Medline, Embase, Cochrane database, which were from Chinese and English database. The retrieval keywords including methylprednisolone, dexamethasone, and sudden deafness and the quality evaluation was used to follow the Newcastle-Ottawa Scale (NOS).Using the RevMan5.3 software for Meta analysis, the risk ratio (RR) value indicators and 95% CI as the study effects, the test of heterogeneity indexed choosing I² and P value. Then sensitivity of the inspection and subgroup analyses were done, Egger's test were used to evaluate the publication bias.If the study indicated publication bias, using trim and filling method would be used to make an evaluation. Result By comparison of the two groups for the treatment of curative effect of sudden deafness, Z=4.91(P<0.000 1), RR(95% CI):1.20(1.12-1.29), the difference was statistically significant (P< 0.05).Subgroup analysis in systemic medication group Z=5.23(P<0.000 01), RR(95% CI):1.28(1.17-1.41), the difference was statistically significant (P<0.05). Local drug group Z=5.99(P<0.000 01), RR(95% CI):1.30(1.19-1.42), the difference was statistically significant (P<0.05).Sensitivity analysis:Z=6.83(P<0.000 01), RR(95% CI):1.19(1.13-1.26), the difference was statistically significant too(P<0.05). Conclusion The efficacy of methylprednisolone for the treatment of sudden deafness is better than the dexamethasone for the treatment of sudden deafness.

Key words: methylprednisolone, dexamethasone, sudden deafness, Meta-analysis

CLC Number:

R764

Gao Zhanmei, Song Yang, Liu Hua, Wen Changlong, Sun Haiyang. Efficacy comparison of methylprednisolone and dexamethasone treatment of sudden deafness: a system review and Meta-analysis[J]. Journal of Capital Medical University, 2018, 39(2): 265-271.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.02.020

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I2/265

References

[1] 中华耳鼻咽喉头颈外科杂志编辑委员会中华医学会耳鼻咽喉头颈外科学分会. 突发性聋的诊断和治疗指南(2005年,济南)[J]. 中华耳鼻咽喉头颈外科杂志, 2006, 41(5):569-569.
[2] 罗杰,冷卫东.系统评价/Meta分析理论与实践[M].北京:军事医学科学出版社,2013:81-82.
[3] Higgins J P T, Green S. Cochrane handbook for systematic reviews of interventions version 5. 1. 0[EB/OL].(updated March 2011)[2018-01-25]. http://handbook.cochrane.org/.
[4] 韦一, 王德乐, 王韶鉴,等. 地塞米松与甲泼尼龙治疗突发性耳聋的临床疗效对比[J]. 中国全科医学, 2014,17(27):3194-3196.
[5] 王明明, 樊兆民, 侯志强,等. 糖皮质激素局部注射与全身应用在特发性突发性聋分型治疗中的疗效[J]. 中华耳鼻咽喉头颈外科杂志, 2014, 49(1):11-15.
[6] 覃宏康, 何中扬, 零兴勤,等. 耳后注射与全身用激素治疗突发性耳聋的疗效分析[J]. 微创医学, 2015, 10(4):551-554.
[7] 陈爱平. 耳后注射糖皮质激素治疗内耳疾病的实验研究[D]. 济南:山东大学, 2016.
[8] 陈晓华, 秦兆冰. 地塞米松与甲泼尼龙治疗突发性耳聋的临床疗效对比[J]. 中国继续医学教育, 2016, 8(15):170-171.
[9] 何碧云, 张柱. 甲泼尼龙与地塞米松治疗突发性耳聋的临床效果[J]. 中国当代医药, 2016, 23(32):130-132.
[10] 李谊, 岳玮, 张灵敏,等. 甲泼尼龙琥珀酸钠耳后注射治疗伴2型糖尿病突发性耳聋的临床效果观察[J]. 临床合理用药杂志, 2016, 9(8):7-8.
[11] 石琰. 耳后骨膜下注射甲泼尼龙琥珀酸钠对突发性耳聋的疗效[J]. 世界最新医学信息文摘:电子版, 2016, 16(82):151-152.
[12] 王丹丹. 地塞米松与甲泼尼龙治疗突发性耳聋患者的临床效果[J]. 中国药物经济学, 2016,11(2):39-41.
[13] 王雯. 地塞米松与甲泼尼龙治疗突发性耳聋的临床疗效对比分析[J]. 临床医药文献电子杂志, 2016, 3(55):11020-11020.
[14] 王晓宇. 耳后注射治疗突发性耳聋的疗效分析[J]. 基层医学论坛, 2016, 20(13):1782-1783.
[15] 谢怡. 甲泼尼龙治疗青少年不同类型突发性耳聋的临床效果[J]. 中国当代医药, 2016, 23(8):107-110.
[16] 张运. 耳后骨膜下注射甲基强的松龙治疗突发性耳聋临床疗效分析[D]. 蚌埠:蚌埠医学院, 2016.
[17] Berjis N, Soheilipour S, Musavi A, et al. Intratympanic dexamethasone injection vs methylprednisolone for the treatment of refractory sudden sensorineural hearing loss[J]. Adv Biomed Res, 2016, 5:111.
[18] 朱皓华. 地塞米松与甲泼尼龙治疗突发性耳聋的临床效果比较[J]. 当代医学, 2016, 22(10):160-161.
[19] 刘慧巧, 陶静, 汤剑芳. 甲泼尼龙琥珀酸钠耳后注射治疗伴2型糖尿病突发性耳聋的临床效果[J]. 中国现代医生, 2017, 55(24):82-84.
[20] 王远强, 闫继宏, 开依赛尔. 探讨甲泼尼龙琥珀酸钠耳后注射治疗伴2型糖尿病突发性耳聋的临床效果[J]. 智慧健康, 2017, 3(2):22-24.
[21] 李新华. 地塞米松与甲泼尼龙治疗突发性耳聋的疗效比较[J]. 中国医药指南, 2017(31).154-155.
[22] 刘栖如, 刘海兵. 鼓室内注射甲基泼尼松龙与地塞米松治疗难治性突发性耳聋疗效比较[J]. 临床合理用药杂志, 2017, 10(20):22-23.
[23] 易虹. 耳后注射甲强龙对全聋型突发性聋疗效分析[J]. 中国医药科学, 2017, 7(8):21-24.
[24] 王晓明, 温丽慧, 吕忠. 耳后注射甲泼尼龙琥珀酸钠与地塞米松治疗平坦型突发性聋的对比研究[J]. 中国耳鼻咽喉头颈外科, 2017, 24(1):28-30.
[25] 廖俊. 耳后注射甲泼尼龙琥珀酸钠联合常规药物治疗重度突发性耳聋的疗效[J]. 世界临床医学, 2017, 11(17):16.
[26] Lai D, Zhao F, Jalal N, et al. Intratympanic glucocorticosteroid therapy for idiopathic sudden hearing loss:Meta-analysis of randomized controlled trials[J]. Medicine, 2017, 96(50):e8955.