Expression of PGRMC1 in breast cancer tissue and its correlation with clinicopathological features

doi:10.3969/j.issn.1006-7795.2018.02.021

Abstract

Abstract: Objective To analyse the expression profile of immunohistochemical indicators progesterone receptor membrane component 1 (PGRMC1), estrogen receptor (ER), progestogen receptor (PR), Ki-67 and human epidermal growth factor receptor-2 (Her-2) in breast cancer tissues, benign breast tumor tissues and normal breast tissues, and evaluate the correlations between the expressions of PGRMC1 and other indicators in breast cancer tissues and benign breast tumor tissues. Methods Sixty cases of breast cancer tissue samples, 30 cases of benign breast tumor tissue and 30 cases of normal breast tissue samples (from the breast benign tumor mammotome minimally invasive rotary cutting around 1 cm of normal tissue, pathological assay revealed no abnormal breast tissue) were selected between September 2015 and January 2015. All the sources of the tissues were diagnosed by a hollow needle biopsy or postoperative histologic examination. Immunohistochemical method was used to detect breast cancer tissues, benign breast tumor tissues and normal breast tissues in the expression of PGRMC1, ER, PR, Ki-67 and Her-2, and analyze the correlations of PGRMC1 expression in breast cancer and benign breast tumor tissues with other indicators. Results Expression rate of PGRMC1:breast cancer group (68.3%) > benign breast tumor group (26.7%) > normal control group (6.7%), the difference between groups was statistically significant (P<0.01). Expression rate of ER:breast cancer group (58.3%) > benign breast tumor group (43.3%) > normal control group (23.3%), the difference between groups was statistically significant (P<0.01). Expression rate of ki-67:breast cancer group (66.7%) > benign breast tumor group (36.7%) > normal control group (13.3%), the difference between groups was statistically significant (P<0.01). The expression of PGRMC1 in breast cancer group was positively correlated with ER expression (OR=3.593,95%CI:1.131-11.418), and there was no correlation with the expressions of PR, ki-67 and Her-2. Conclusion The expression level of PGRMC1 in breast cancer group was significantly higher than that in benign breast tumor group and control. The expression of PGRMC1 in breast cancer tissue was positively correlated with ER expression, and there was no correlation with PR, ki-67 and Her-2 expression.

Key words: breast cancer, immunohistochemistry, progesterone receptor membrane component 1(PGRMC1), estrogen receptor, progestogen receptor, Ki-67, human epidermal growth factor receptor-2, correlation

CLC Number:

G306.4

Wang Lijuan, Ruan Xiangyan, Zhao Yue. Expression of PGRMC1 in breast cancer tissue and its correlation with clinicopathological features[J]. Journal of Capital Medical University, 2018, 39(2): 272-276.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.02.021

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I2/272

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