Core pathogenesis of sepsis in rats treated with three kinds of traditional Chinese medicine

doi:10.3969/j.issn.1006-7795.2019.03.004

Journal of Capital Medical University ›› 2019, Vol. 40 ›› Issue (3): 340-343.doi: 10.3969/j.issn.1006-7795.2019.03.004

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Core pathogenesis of sepsis in rats treated with three kinds of traditional Chinese medicine

Guo Yuhong^1,2, Xu Xiaolong^1,2,3, Huang Po¹, Liu Qingquan^1,2,3

1. Department of Intensive Care Unit, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;
2. Beijing Key Laboratory of Basic Research on Infectious Diseases of Traditional Chinese Medicine, Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China;
3. Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China

Received:2019-03-15 Online:2019-05-21 Published:2019-06-13
Supported by:
This study was supported by National Natural Science Foundation of China (81673934),Capital Health Development Research Project (SF2018-1-1161).

Abstract

Abstract: Objective To observe the effect of Yiqiwenyang-Huoxue herbs on the mortality of sepsis in rats. Methods Septic rats were divided randomly into seven groups (control group, middle and low dose groups of Yiqiwenyang, middle and low dose groups of Yiqiwenyang Huoxue, and middle and low dose groups of Fuzhengtouxie). The rats were intragastricly administrated at 2, 12, 24, 36, 48 and 60 hours after operation, and the survival conditions of rats were observed.Results The mortality of sepsis rats in Yiqiwenyang Houxue group was significantly lower than that in Fuzhengtouxie group and Yiqiwenyang group. Conclusion The deficiency of Qi and stasis toxin blocking collaterals are the core pathogenesis of sepsis.

Key words: sepsis, traditional Chinese medicine (TCM) treatment, pathogenesis

CLC Number:

R242

Guo Yuhong, Xu Xiaolong, Huang Po, Liu Qingquan. Core pathogenesis of sepsis in rats treated with three kinds of traditional Chinese medicine[J]. Journal of Capital Medical University, 2019, 40(3): 340-343.

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Core pathogenesis of sepsis in rats treated with three kinds of traditional Chinese medicine

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