Correlation between endothelial function and left ventricular hypertrophy in patients with untreated mild hypertension

doi:10.3969/j.issn.1006-7795.2019.03.009

Abstract

Abstract: Objective To compare the endothelial function in patients with untreated mild hypertension with left ventricular hypertrophy(LVH), and to explore the correlation between endothelial function and left ventricular hypertrophy. Methods A retrospective analysis of 174 patients with untreated mild essential hypertension who were admitted to the Department of Cardiology, Xuanwu Hospital, Capital Medical University from April 2016 to October 2016 was performed. According to the results of echocardiography, the patients were divided into the hypertension with LVH group and the hypertension without LVH group, and the clinical characteristics, endothelial function and echocardiographic parameters were compared with each other. Logistic regression was used to analyze the correlation between left ventricular hypertrophy and endothelial function.Results Compared with hypertension without left ventricular hypertrophy group, reactive hyperemia index was lower and the proportion of endothelial dysfunction (reactive hyperemia index <1.67) was higher in patients with hypertension and left ventricular hypertrophy (P<0.05). Multivariate Logistic regression analysis showed that the reaction hyperemia index was still associated with left ventricular hypertrophy (OR=0.230, P=0.001). Conclusion The endothelial function of patients with untreated mild essential hypertension is closely related to left ventricular hypertrophy. The decrease of reactive hyperemia index is an important risk factor for left ventricular hypertrophy in patients with untreated mild hypertension.

Key words: hypertension, left ventricular hypertrophy, reactive hyperemia index

CLC Number:

R544.1

Zhu Guohua, Sun Xipeng, Tang Hua, Hua Qi. Correlation between endothelial function and left ventricular hypertrophy in patients with untreated mild hypertension[J]. Journal of Capital Medical University, 2019, 40(3): 369-373.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2019.03.009

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2019/V40/I3/369

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