Research advances on the regulation and mechanism of microRNA-181b on cardiovascular diseases

doi:10.3969/j.issn.1006-7795.2019.03.014

Abstract

Abstract: Cardiovascular disease is one of the diseases with the highest morbidity and mortality. Numerous studies have shown that microRNA181b(miR-181b)can regulate the physiological and pathological state of the cardiovascular system by regulating the relevant target genes in cardiovascular tissues and regulating the expression of cytokines, proteases and receptors. It plays an important regulatory role in cardiovascular diseases such as hypertension, atherosclerosis, arterial valve calcification, myocardial fibrosis, cardiac hypertrophy and myocarditis. This article reviewed the research progresses on the role and mechanism of miR-181b in cardiovascular disease.

Key words: microRNA-181b, cardiovascular disease, mechanism of action

CLC Number:

Qi Yuan, Jing Li. Research advances on the regulation and mechanism of microRNA-181b on cardiovascular diseases[J]. Journal of Capital Medical University, 2019, 40(3): 396-401.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2019.03.014

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2019/V40/I3/396

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