Application value of detection of thinprep cytology test and human papillomavirus E6/E7 mRNA in cervical disease screening

doi:10.3969/j.issn.1006-7795.2019.04.016

Abstract

Abstract: Objective To investigate the application value of thinprep cytology test (TCT) combined with human papillomavirus (HPV)E6/E7 mRNA detection in cervical disease screening.Methods A total of 538 cases were detected with gynecological disorders received TCT,HPV E6/E7 and colposcopy cervical biopsy. To compare the diagnostic value of TCT or HPV E6/E7 mRNA alone with combined TCT and HPV E6/E7 mRNA in cervical lesion screening. Results Compared with pathological examination for cervical disease diagnosis, the sensitivity and specificity of TCT was 66.56% and 53.57% respectively, the sensitivity and specificity of HPV E6/E 7 mRNA was 74.84% and 77.68% respectively while the sensitivity and specificity of joint detection of TCT and HPV E6/E7 mRNA was 99.68% and 39.29% respectively. Conclusion The joint detection of TCT and HPV E6/E7 mRNA raises the sensitivity remarkably in cervical disease screening, reduces missed clinic diagnosis rate and contributes to clinic cervical disease screening.

Key words: thinprep cytology test (TCT), human papillomavirus (HPV)E6/E7 mRNA, cervical disease

CLC Number:

Wang Junfei, Shen Shuna, Zhu Ping. Application value of detection of thinprep cytology test and human papillomavirus E6/E7 mRNA in cervical disease screening[J]. Journal of Capital Medical University, 2019, 40(4): 578-581.

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