Effects of cornel iridoid glycoside on cognitive function and tau phosphorylation in rats with traumatic brain injury

doi:10.3969/j.issn.1006-7795.2020.03.015

Abstract

Abstract: Objective To investigate the effects of cornel iridoid glycoside (CIG) on cognitive impairment and tau hyperphosphorylation induced by traumatic brain injury (TBI) in rats. Methods TBI model was induced with the modified Feeney's method on the right cerebral cortex in male adult rats. Drug administration started at 3 h after TBI surgery and lasted for 28 days. The passive avoidance memory function was measured by step through test. Fluoro Jade B staining was used to detect neurodegeneration in the brain. The expression of tau phosphorylation was determined by Western blotting. Results At the 28th day after TBI surgery, the model group rats showed an increase in the error times in the step through test, the number of degenerated neurons in the hippocampus, and the expression of phosphorylated tau protein in the wound site. Intragastric administration of CIG for 28 days ameliorated the passive avoidance memory impairment, alleviated neurodegenerative lesions in the hippocampus, and decreased the hyperphosphorylation of tau protein at Thr205 and Ser309 sites near the injury site in TBI rats. Conclusion The results suggest that CIG may be beneficial to treating the cognitive impairment induced by brain trauma.

Key words: cornel iridoid glycoside, traumatic brain injury, cognitive impairment, tau hyperphosphorylation, neurodegeneration

CLC Number:

R743

Ma Denglei, Zhang Xu, Zhang Li, Li Yali, Zhang Lan, Li Lin. Effects of cornel iridoid glycoside on cognitive function and tau phosphorylation in rats with traumatic brain injury[J]. Journal of Capital Medical University, 2020, 41(3): 397-402.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2020.03.015

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2020/V41/I3/397

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