Application of endocytoscopy in the valuation of colorectal lesions

doi:10.3969/j.issn.1006-7795.2022.02.010

Abstract

Abstract: Endocytoscopy (EC) is an ultra-high magnification endoscope. The latest generation of EC can enlarge the image by 520 times. Combined with staining or narrow-band imaging technology, it can observe and diagnose colorectal lesions at the cellular level to achieve in vivo evaluation close to pathological biopsy. We reviewed recent research on EC classification and application of colorectal polyps, tumors, and inflammatory bowel diseases. We also focused on preparation before EC examinations to obtain EC images with better quality.

Key words: endocytoscopy, colorectal lesions, polyp, tumor, inflammatory bowel disease(IBD)

CLC Number:

R574

Ma Mingyang, Wang Jiewei, Li Peng. Application of endocytoscopy in the valuation of colorectal lesions[J]. Journal of Capital Medical University, 2022, 43(2): 221-226.

References

[1] Matsuda T, Fujii T, Saito Y, et al. Efficacy of the invasive/non-invasive pattern by magnifying chromoendoscopy to estimate the depth of invasion of early colorectal neoplasms[J]. Am J Gastroenterol, 2008, 103(11): 2700-2706.
[2] Kudo S E, Misawa M, Wada Y, et al. Endocytoscopic microvasculature evaluation is a reliable new diagnostic method for colorectal lesions (with video)[J]. Gastrointest Endosc, 2015, 82(5): 912-923.
[3] Kudo S E, Mori Y, Wakamura K, et al. Endocytoscopy can provide additional diagnostic ability to magnifying chromoendoscopy for colorectal neoplasms[J]. J Gastroenterol Hepatol, 2014, 29(1): 83-90.
[4] Kutsukawa M, Kudo S E, Ikehara N, et al. Efficiency of endocytoscopy in differentiating types of serrated polyps[J]. Gastrointest Endosc, 2014, 79(4): 648-656.
[5] Takamaru H, Wu S Y S, Saito Y. Endocytoscopy: technology and clinical application in the lower GI tract[J]. Transl Gastroenterol Hepatol, 2020, 5: 40.
[6] Sasajima K, Kudo S E, Inoue H, et al. Real-time in vivo virtual histology of colorectal lesions when using the endocytoscopy system[J]. Gastrointest Endosc, 2006, 63(7): 1010-1017.
[7] Kimoto Y, Ohata K, Takita M, et al. New techniques in endocytoscopy: submucosal injection heightens the visibility[J]. Endoscopy, 2021, 53(7): E245-E246.
[8] Kim K O, Kim E Y. Application of artificial intelligence in the detection and characterization of colorectal neoplasm[J]. Gut Liver, 2021, 15(3): 346-353.
[9] Ichimasa K, Kudo S E, Mori Y, et al. Double staining with crystal violet and methylene blue is appropriate for colonic endocytoscopy: an in vivo prospective pilot study[J]. Dig Endosc, 2014, 26(3): 403-408.
[10] Sano Y, Horimatsu T, Fu K I, et al. Magnifying observation of microvascular architecture of colorectal lesions using a narrow-band imaging system[J]. Dig Endosc, 2006, 18(S1): S44-S51.
[11] Rotondano G, Bianco M A, Salerno R, et al. Endocytoscopic classification of preneoplastic lesions in the colorectum[J]. Int J Colorectal Dis, 2010, 25(9): 1111-1116.
[12] Kudo T, Kudo S E, Wakamura K, et al. Diagnostic performance of endocytoscopy for evaluating the invasion depth of different morphological types of colorectal tumors[J]. Dig Endosc, 2015, 27(7): 754-761.
[13] Kudo T, Kudo S E, Mori Y, et al. Classification of nuclear morphology in endocytoscopy of colorectal neoplasms[J]. Gastrointest Endosc, 2017, 85(3): 628-638.
[14] Mori Y, Kudo S, Ikehara N, et al. Comprehensive diagnostic ability of endocytoscopy compared with biopsy for colorectal neoplasms: a prospective randomized noninferiority trial[J]. Endoscopy, 2013, 45(2): 98-105.
[15] Ocvirk S, OKeefe S J D. Dietary fat, bile acid metabolism and colorectal cancer[J]. Semin Cancer Biol, 2021, 73: 347-355.
[16] Utsumi T, Sano Y, Iwatate M, et al. Prospective real-time evaluation of diagnostic performance using endocytoscopy in differentiating neoplasia from non-neoplasia for colorectal diminutive polyps (≤5 mm)[J]. World J Gastrointest Oncol, 2018, 10(4): 96-102.
[17] Kataoka S, Kudo S E, Misawa M, et al. Endocytoscopy with NBI has the potential to correctly diagnose diminutive colorectal polyps that are difficult to diagnose using conventional NBI[J]. Endosc Int Open, 2020, 8(3): E360-E367.
[18] Kudo T, Suzuki K, Mori Y, et al. Endocytoscopy for the differential diagnosis of colorectal low-grade adenoma: a novel possibility for the “resect and discard” strategy[J]. Gastrointest Endosc, 2020, 91(3): 676-683.
[19] Rex D K, Ahnen D J, Baron J A, et al. Serrated lesions of the colorectum: review and recommendations from an expert panel[J]. Am J Gastroenterol, 2012, 107(9): 1315-1329.
[20] Ogawa Y, Kudo S E, Mori Y, et al. Use of endocytoscopy for identification of sessile serrated adenoma/polyps and hyperplastic polyps by quantitative image analysis of the luminal areas[J]. Endosc Int Open, 2017, 5(8): E769-E774.
[21] Takeda K, Kudo S E, Mori Y, et al. Magnifying chromoendoscopic and endocytoscopic findings of juvenile polyps in the colon and rectum[J]. Oncol Lett, 2016, 11(1): 237-242.
[22] Tsuruta O, Toyonaga A, Ikeda H, et al. Clinicopathological study of superficial-type invasive carcinoma of the colorectum[J].Int J Oncol, 1997, 10(5): 1003-1008.
[23] Hirose M, Fukui H, Igarashi Y, et al. Detection of desmoplastic reaction in biopsy specimens is useful for predicting the depth of invasion of early colorectal cancer: a Japanese collaborative study[J]. J Gastroenterol, 2010, 45(12): 1212-1218.
[24] Sugihara Y, Kudo S E, Miyachi H, et al. In vivo detection of desmoplastic reaction using endocytoscopy: a new diagnostic marker of submucosal or more extensive invasion in colorectal carcinoma[J]. Mol Clin Oncol, 2017, 6(3): 291-295.
[25] Sako T, Kudo S E, Miyachi H, et al. A novel ability of endocytoscopy to diagnose histological grade of differentiation in T1 colorectal carcinomas[J]. Endoscopy, 2018, 50(1): 69-74.
[26] Nakamura H, Kudo S E, Misawa M, et al. Evaluation of microvascular findings of deeply invasive colorectal cancer by endocytoscopy with narrow-band imaging[J]. Endosc Int Open, 2016, 4(12): E1280-E1285.
[27] 胡红娜, 章礼久, 宋莎莎. 结直肠侧向发育型肿瘤内镜下诊治的临床研究[J]. 中华全科医学, 2021, 19(7): 1103-1106, 1195.
[28] Bessho R, Kanai T, Hosoe N, et al. Correlation between endocytoscopy and conventional histopathology in microstructural features of ulcerative colitis[J]. J Gastroenterol, 2011, 46(10): 1197-1202.
[29] Neumann H, Vieth M, Grauer M, et al. OP06 endocytoscopy allows accurate in vivo differentiation of mucosal inflammatory cells in IBD a pilot study[J]. J Crohns Colitis, 2012, 6(Suppl-1): S3.
[30] Nakazato Y, Naganuma M, Sugimoto S, et al. Endocytoscopy can be used to assess histological healing in ulcerative colitis[J]. Endoscopy, 2017, 49(6): 560-563.
[31] Maeda Y, Kudo S E, Mori Y, et al. Fully automated diagnostic system with artificial intelligence using endocytoscopy to identify the presence of histologic inflammation associated with ulcerative colitis (with video)[J]. Gastrointest Endosc, 2019, 89(2): 408-415.
[32] Fukuda T, Naganuma M, Sugimoto S, et al. Efficacy of therapeutic intervention for patients with an ulcerative colitis Mayo endoscopic score of 1[J]. Inflamm Bowel Dis, 2019, 25(4): 782-788.
[33] Maeda Y, Kudo S E, Ogata N, et al. Endocytoscopic intramucosal capillary network changes and crypt architecture abnormalities can predict relapse in patients with an ulcerative colitis Mayo endoscopic score of 1[J]. Dig Endosc, 2020, 32(7): 1082-1091.
[34] Cipolletta L, Bianco M A, Rotondano G, et al. Endocytoscopy can identify dysplasia in aberrant crypt foci of the colorectum: a prospective in vivo study[J]. Endoscopy, 2009, 41(2): 129-132.
[35] Barua I, Mori Y, Bretthauer M. Colorectal polyp characterization with endocytoscopy: ready for widespread implementation with artificial intelligence?[J]. Best Pract Res Clin Gastroenterol, 2021, 52/53: 101721.