17β-estradiol and Phytoestrogen α-zearalanolon Uterus Enlarging in Ovariectomized Rats

Abstract

Abstract:

The aim of this study was to investigate and compare the effects of 17β-estrad iol and phytoestrogen α-zearalanol(ZAL) on uterus enlarging in ovariectomized(OVX) rats. OVX rats were injected intramuscularly with 17β-estradiol or ZAL (1 mg/kg) for five weeks. The concentrations of plasma estradiol were measured by radioimmunoassay. Separate the uterus from rats and calculate the ratio of ut eri weight(g)/body weight(kg) then make pathology slice of uterus tissue. It was found that plasma estradiol levels of OVX+17β-estradiol rats were signifi cantly higher than th at of OVX rats, while estradiol levels of OVX+ZAL were significantly lower than that of OVX+17β-estradiol rats. ZAL had slighter effect on uterus enlarging in ovariectomized rats compared with 17β-estradiol. These results suggest that Z AL has less stimulation on uterus than 17β-estradiol, which maybe work as one of selectively estrogen receptor modulator(SERM).

Key words: phytoestrogen, &alpha, -zearalanol, 17&beta, -estradiol, variectomized rats, uterus

CLC Number:

Q492.5

Wang Wen;Yang Hui;Wang Hongxia;Zhang Like . 17β-estradiol and Phytoestrogen α-zearalanolon Uterus Enlarging in Ovariectomized Rats[J]. Journal of Capital Medical University, 2005, 26(1): 51-54.

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17β-estradiol and Phytoestrogen α-zearalanolon Uterus Enlarging in Ovariectomized Rats

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