Abstract: Objective To investigate the prevalence of depression, its impact on quality of life of Parkinson's disease(PD) and its associated factors. Methods The detailed clinical information of 445 patients with idiopathic PD were recorded. Hamilton Depression Rating Scale(HAMD) were used to assess the severity of depression in PD patients. Unified Parkinson's Disease Rating Scale(UPDRS) were used to evaluate the severity of PD. The Medical Outcomes Study 36-Item Short-Form Health Survey(SF-36) was used to assess the quality of life. The data was calculated with SPSS statistic software. Results The average score of HAMD was 7.42±6.44. Among the 445 patients, 61.2% patients had no depressive symptoms, 30.2% patients had minor depression, 6.5% had moderate depression, and 2.1% had severe depression. Depression had significantly impacted the quality of life of PD in physical functioning, role-physical, role-emotional, vitality, mental health, social functioning, bodily pain, general health, and reported health transition(P<0.001). Logistic regression analysis showed that total UPDRS scores were positively correlated with depression. Conclusion The depression in patients with PD was mainly minor depression and it had significant negative effect on quality of life in PD patients. The more severe the disease is the more likely to develop depression.

Key words: Parkinson's disease, depression, quality of life