Risk factors on anastomotic leakage after low anterior resection of rectal cancer

doi:10.3969/j.issn.1006-7795.2017.05.018

Abstract

Abstract: Objective To investigate the risk factors on anastomotic leakage after low anterior resection of rectal cancer so as to provide a basis for the prevention and treatment of anastomotic leakage, thus reducing the incidence of leakage. Methods The data of 261 rectal cancer patients undergoing low anterior resection from January 1st 2013 to March 31st 2017 were recruited. All patients experienced a total mesorectal excision (TME) operation. χ² test was performed for univariate analysis, and Logistic regression test was carried out for multivariate correlation analysis. Results The incidence of anastomotic leakage was 6.89% (18/261). Multivariate analysis showed that the occurrence of anastomotic leakage was closely correlated to neoadjuvant chemoradiation (OR=3.498,P=0.024) and combined with other organ surgery (OR=10.834, P=0.003). Conclusion Neoadjuvant chemoradiation and combined with other organ surgery were considered as independent risk factors for anastomotic leakage after anterior resection of rectal cancer. According to the relevant risk factors, the effective measures should be taken to reduce the incidence of anastomotic leakage.

Key words: rectal cancer, low anterior resection, anastomotic leakage, risk factors

CLC Number:

R753.3

Xu Yi, Zhao Xiaomu, Sun Wuqing, Ma Jian, Wang Yueyue, Wang Jin. Risk factors on anastomotic leakage after low anterior resection of rectal cancer[J]. Journal of Capital Medical University, 2017, 38(5): 727-732.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.05.018

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I5/727

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