An event-related potential study of dysfunction of conflict monitoring in patients with schizophrenia

doi:10.3969/j.issn.1006-7795.2018.05.001

Abstract

Abstract: Objective To investigate the deficits of conflict monitoring function in patients with schizophrenia, and to understand the role of N270 in evaluating the cognitive functions of patients with schizophrenia. Methods Totally 14 schizophrenia patients and 20 healthy subjects were recruited. The electroencephalogram (EEG) data were recorded using EGI 128-channel EEG systems. Two consecutive faces were presented to the subjects to induce event-related potentials. The experimental task was to judge whether the two faces were the same or different. Results Face inconsistencies (conflict conditions) induced a conflicting negative wave, N270, but no N270 was observed under face matching conditions. Compare with the healthy group, the peak latency of the N270 component was significantly delayed at the O1, O2, P3, and P4 electrodes in the patient group, with no significant difference in amplitude between the two groups. Conclusion There was a significant abnormality in the incubation period of N270 in patients with schizophrenia, suggesting the defect in their conflict monitoring function. Schizophrenia may adopt a different processing mechanism for the conflict of information. N270 can serve as an objective indicator of the conflict handling capacity to evaluate the cognitive function of patients with schizophrenia.

Key words: schizophrenia, event-related potential, conflict monitoring, N270

CLC Number:

R749.3

Bian Zhiming, Wang Changming, Liu Chenyang, Zhang Xiujun, Ma Xin. An event-related potential study of dysfunction of conflict monitoring in patients with schizophrenia[J]. Journal of Capital Medical University, 2018, 39(5): 625-629.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.05.001

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I5/625

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