mpact of prenatal stress on evoked expression of c-Fos in emotion-related brain areas

doi:10.3969/j.issn.1006-7795.2023.06.017

Abstract

Abstract: Objective To elucidate the impact of prenatal stress (PS) on evoked expression of c-Fos in select emotion-related brain areas. Methods An experimental model of maternal exposure to chronic restraint stress in rats was employed as PS model. Subsequently, we assessed c-Fos and NeuN staining by immunofluorescence staining method in various brain regions of PS offspring rats, including the medial prefrontal cortex (mPFC), basolateral amygdala (BLA), ventral hippocampus (VH), and ventrolateral periaqueductal gray (vlPAG). Results Our findings revealed a significant decrease in the density and proportion of c-Fos positive neurons in the mPFC and BLA regions of PS-exposed offspring compared to control offspring. The density of c-Fos positive neurons in the VH region reduced in PS-exposed offspring, while no change was observed in the vlPAG region. Conclusion Our results indicated that PS induced a decreased density of stress-sensitive neurons in mPFC,BLA and VH brain regions, suggesting a potential underlying mechanism for the observed behavioral changes.

Key words: prenatal stress, c-Fos, emotion-related brain regions, depression behavior

CLC Number:

R749.4

Li Zhiheng, Yu Xin, Yuan Ying, Xu Zhiqing. mpact of prenatal stress on evoked expression of c-Fos in emotion-related brain areas[J]. Journal of Capital Medical University, 2023, 44(6): 1014-1021.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2023.06.017

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2023/V44/I6/1014

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