The Clawed Jirds(Meriones Unguiculatus) as an Animal Model for Intestinal Amoebiasis

Journal of Capital Medical University ›› 1991, Vol. 12 ›› Issue (3): 197-200.

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The Clawed Jirds(Meriones Unguiculatus) as an Animal Model for Intestinal Amoebiasis

Lu Siqi¹, Guo Zengzhu², Ji Aiping², Wang Zhengyi(Wang Cheng-i)², Li Xueqing³

1. Department of Parasitology, Capital Institute of Medicine;2. Beijing Tropical Medicine Research Institute;3. Department of Pathoanatonzy, Capital Institute of Medicine

Received:1990-05-08 Revised:1900-01-01 Online:1991-07-15 Published:1991-07-15

Abstract

Abstract: Polyxenically cultivated Entamoeba histolytica trophozoites(HB₁ and HT₁ strains)were inoculated into the cecum of the clawed jirds (Meriones unguiculatus) after laparotomy.The histopathological changes occurred in the colon,liver,spleen and mesenteric lymph nodes of the jirds were studied from 7 to 20 days postinoculation.Of 16 inoculated jirds,12 were infected.Seven of the infected jirds showed early invasive lesions with superficial ulcerations and lymphocytic and giant cell infiltrations in every layer of the intestinal wall.Small amebic liver abscess and small focal necrosis in the mesenteric lymph nodes were found in one jird.

Key words: intestinal amoebiasis, clawed jird (Meriones unguiculatus), animal model

Lu Siqi;Guo Zengzhu;Ji Aiping;Wang Zhengyi(Wang Cheng-i);Li Xueqing. The Clawed Jirds(Meriones Unguiculatus) as an Animal Model for Intestinal Amoebiasis[J]. Journal of Capital Medical University, 1991, 12(3): 197-200.

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The Clawed Jirds(Meriones Unguiculatus) as an Animal Model for Intestinal Amoebiasis

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