Abstract: We studied the effects of Mycobacterial polysaccharides(MPS)on the suppression function of cyclophosphamide to BALB/C mice bone marrow.The results showed that 1.0 mg/kg of MPS had enhance effects on the GM-CFU(control-1,316.5±34.6,MPS group,454.5±19.1 ,P<0.05;control-2,208.7±43.7,MPS group,437.8±54.1, P<0.02). However,in 0.15 mg/ kg and 1.0 mg/kg of MPS,the levels of GM-CSF activity in sera of mice raised obviously;0.15 mg/kg of MPS could stimulate mice to produce 500 U GM-CSF per 0.1 mL sera,1.0 mg/kg of MPS could make mice induce 850 U GM-CSF per 0.1 mL sera.Analysis indicated that the activity levels of the MPS was the same as Japanese Z-100,and the hemopoietic effects of MPS may be indirect by stimulating monocytes and T lymphacytes indirectly.

Key words: MPS, mouse hemopoietic progenitor(GM-CFU), GM-CSF activity levels of sera