Abstract: The relationship between endocrine hormone and obesity was studied in 75 simple obese children of ages 6～15 and 59 age matched healthy children. A significant increase in insulin and E2 and decrease in human growth hormone and prolactin in the obese than the normal controls were observed(P all<0.01). There were no differences between two groups in triiodothyronine and COR. Serum insulin level was correlated positively to body mass index(r=0.61,P<0.001), age(r=0.40,P<0.01),height(r=0.50,P<0.001)and weight(r=0.62,P<0.001). Stepwise multivariate regression analysis disclosed that body mass index alone and jointly correlatedwith insulin level.

Key words: simple obese children, insulin, E₂, growth hormone, prolactin