Abstract: In order to investigate characteristic of migrating motor complex (MMC) in health and diabetic patients ,51 type Ⅱdiabetes patients (NIDDM) and 16 healthy volunteers were studied after an overnight fast by means of 6 channel computerized manometry of antroduodenal region for at least 240 min.The results showed that phase Ⅲofthe MMCoriginated in the antru m in 14/51(27.5 %) of the diabetic patients, which was significantly less than thatin 12/16(75.0 %) of the healthys(P< 0.01).Phase Ⅲwas absentin 21/51(41.1 %) ofthe patients and in 2/16(12.5 %) ofthe controls (P< 0.05).The amplitude of phase Ⅲin antru m was lower in the diabetic group than that in the control 〔(8.1 ± 3.5) kPa vs (10.5 ±3.1) kPa, P< 0.05〕. Period of phase Ⅱwas also longer in the diabetes patients than normal subjects 〔(27.9 ±13.1) min vs (19.9 ±6.1) min ,P< 0.01〕.Phase Ⅱand phase Ⅲwere all absent in 6/51(11.8 %) of the diabetic patients during 240 min, but it was not obseved in the controls. The results of this study demonstrated that about 70 % NIDDM patients had abnormal MMC even before the clinicalsym ptoms of gastroparesis occured ,and the gastrodudenal manometry might be an useful method in the early diagnosis of diabetic gastrointestinal dismotility.

Key words: diabetes mellitus, gastrodudenal manometry, migrating motor complex