MRI Finding of Parkinsonizm in Primate after MPTP Exposure

Journal of Capital Medical University ›› 2000, Vol. 21 ›› Issue (3): 187-189.

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MRI Finding of Parkinsonizm in Primate after MPTP Exposure

Gu Yebing¹, Li Kuncheng¹, Yao Xinyu¹, Zhang Jinlu², Liu Yujun², Lu Qiang², Xu Qunyuan²

1. Department of Radiology, Xuanwu Hospital, Affiliate of Capital University of Medical Sciences;2. Beijing Institute for Neuroscience, Capital University of Medical Sciences

Received:1999-11-08 Revised:1900-01-01 Online:2000-07-15 Published:2000-07-15

Abstract

Abstract: Five primate models for Parkinsonizm, which was established by 1-methyl-4-pheny-1,2,3,6-tetrahydropyridine(MPTP) injecting through unilateral internal carotid after 6 weeks, were scanned by MR imaging. MRI demonstrated that the area of the substantia nigra decreased and there was foci of increased signal intensity in homolateral on T₂-weighted images. Histological examination showed a loss of tyrosine hydroxylase immunoreactive neurons and pervasive gliosis in the ventral midbrain area on the injection side by Grino staining. The results manifested that MRI can be a modality to evaluating the primate modal of Parkinsonnism after MPTP exposure.

Key words: macaque, Parkinsonizm, magnetic resonance imaging

CLC Number:

R742.5

Gu Yebing;Li Kuncheng;Yao Xinyu;Zhang Jinlu;Liu Yujun;Lu Qiang;Xu Qunyuan. MRI Finding of Parkinsonizm in Primate after MPTP Exposure[J]. Journal of Capital Medical University, 2000, 21(3): 187-189.

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MRI Finding of Parkinsonizm in Primate after MPTP Exposure

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